Community standards

The Proteomics Standards Initiative at twenty years

Deutsch EW, Vizcaíno JA, … Hoffmann N, et al.

J. Proteome Research · 2023 doi: 10.1021/acs.jproteome.2c00637 ↗

The idea

Standards only work when a community maintains them. This review describes how the HUPO Proteomics Standards Initiative governs and evolves the formats and controlled vocabularies used across MS — and where it is heading, including small molecules, quality control and AI-readiness.

Key concepts

An open, publicly reviewed document process ratifies each standard.

Data formats and controlled vocabularies give shared, unambiguous meaning to MS data.

Quality control via mzQC captures metrics for runs and datasets.

What we found

Catalogues the current PSI standards and how each has evolved over 20 years.

Extends the remit toward metabolomics and lipidomics.

Sets a direction of AI-readiness and FAIR, interoperable small-molecule data.